Positive regulation of myoblast proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of myoblast proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP5ME, SRRM2_T983, and USP42_S1007, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myoblast proliferation activity versus ATP5ME in UCEC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP5ME →	+0.242	+0.065	.004	.005	3	4
LSCC	SRRM2_T983 →	-0.339	-0.038	<.001	<.001	3	4
LSCC	USP42_S1007 →	-0.350	-0.034	.001	.003	3	4
OV	SRRM2_T2104 →	-0.619	-0.057	<.001	.005	3	3
HNSC	PROSER2_S212 →	+0.614	+0.054	<.001	.008	3	3
PDAC	ADD3 →	+0.235	+0.057	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000288 vs ATP5ME — UCEC

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