Positive regulation of myoblast proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of myoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD12, ZNF26, and ZNF140, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of myoblast proliferation activity versus SAMD12 in LSCC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SAMD12 →	+0.808	+0.204	.002	.007	3	5
GBM	ZNF26 →	+0.302	+0.619	.001	<.001	3	5
BRCA	ZNF140 →	+0.460	+0.307	.005	<.001	3	5
LSCC	MAPKAPK5 →	+0.358	+0.279	.001	.003	3	5
LUAD	ZFP3 →	+0.405	+0.500	<.001	.006	3	5
LSCC	SETD4 →	+0.436	+0.323	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000288 vs SAMD12 — LSCC

Explore this scatter interactively →