Positive regulation of myoblast proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myoblast proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAS1, EXPH5, and REXO2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCAS1 grouped by Positive regulation of myoblast proliferation-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCAS1 →	+1.597	+0.987	.007	.002	3	4
BONE	EXPH5 →	-0.786	-1.398	.008	.002	3	4
OVARY	REXO2 →	-0.957	-1.186	.006	.001	3	4
STOMACH	ZNF577 →	-2.421	-1.641	<.001	.001	3	4
STOMACH	ENPP5 →	-2.096	-1.412	.002	.005	2	4
LUNG_NSCLC_LUAD	SPATA32 →	-0.391	-0.653	.002	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCAS1 by Positive regulation of myoblast proliferation activity — LARGE_INTESTINE

Explore this box plot interactively →