Positive regulation of myoblast proliferation

Across TCGA cell cohorts, RNA activity of the Positive regulation of myoblast proliferation pathway is significantly associated with the drug response of multiple features, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Axitinib, AZ20, and FS112, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Axitinib grouped by Positive regulation of myoblast proliferation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Axitinib →	-0.876	-0.509	.009	.021	3	1
UPPER_AERODIGESTIVE_TRACT	AZ20 →	-0.496	-0.618	.010	.002	3	1
UPPER_AERODIGESTIVE_TRACT	FS112 →	-0.620	-0.509	.012	.021	3	1
UPPER_AERODIGESTIVE_TRACT	SN-38 →	-0.863	-0.503	.003	.005	3	1
UPPER_AERODIGESTIVE_TRACT	VE-822 →	-1.300	-0.550	.006	.010	3	1
UPPER_AERODIGESTIVE_TRACT	AKT inhibitor VIII →	-0.960	-0.603	.008	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Axitinib by Positive regulation of myoblast proliferation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →