Positive regulation of fibroblast apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of fibroblast apoptotic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are OCLN, NIBAN2, and BSPRY, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast apoptotic process activity versus OCLN in PDAC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	OCLN →	-0.497	-0.075	.001	<.001	3	7
HNSC	NIBAN2 →	-0.355	-0.066	<.001	.001	3	6
BRCA	BSPRY →	-0.537	-0.045	.001	.008	2	7
BRCA	LRBA →	-0.490	-0.095	<.001	<.001	3	6
LUAD	FAM120A →	-0.216	-0.065	<.001	<.001	3	6
HNSC	FNDC3B →	+0.266	+0.073	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000271 vs OCLN — PDAC

Explore this scatter interactively →