Positive regulation of fibroblast apoptotic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of fibroblast apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EFEMP1, SESN3, and BMP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of fibroblast apoptotic process activity versus EFEMP1 in PDAC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	EFEMP1 →	+0.506	+0.246	<.001	<.001	3	3
LSCC	SESN3 →	+0.881	+0.679	.003	.002	2	4
PDAC	BMP6 →	+0.528	+0.157	<.001	.002	3	3
PDAC	SNORA59A →	-0.507	-0.158	<.001	.003	3	3
CCRCC	NECTIN4 →	+0.595	+0.592	.008	.003	3	3
LUAD	COL24A1 →	+0.583	+0.426	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000271 vs EFEMP1 — PDAC

Explore this scatter interactively →