Regulation of fibroblast apoptotic process

Across TCGA cell cohorts, RNA activity of the Regulation of fibroblast apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAN2B1, SRGAP2B, and GAD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAN2B1 grouped by Regulation of fibroblast apoptotic process-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MAN2B1 →	-1.439	-1.365	.004	.005	3	4
PANCREAS	SRGAP2B →	-0.619	-1.059	.007	.001	3	4
CNS	GAD1 →	-1.323	-0.882	.008	.009	3	3
CNS	RELL1 →	-0.594	-0.768	.008	.003	2	4
LUNG_NSCLC_LUSC	COPZ1 →	-0.500	-1.569	.005	.001	3	3
LUNG_NSCLC_LUSC	IL11RA →	-1.434	-1.782	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAN2B1 by Regulation of fibroblast apoptotic process activity — BLOOD_Leukemia

Explore this box plot interactively →