Regulation of sodium-dependent phosphate transport

Across TCGA patient cohorts, RNA activity of the Regulation of sodium-dependent phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL5A2, PELATON, and COL8A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of sodium-dependent phosphate transport activity versus COL5A2 in GBM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL5A2 →	+1.095	+0.174	.001	.001	3	5
GBM	PELATON →	+0.706	+0.207	.002	<.001	3	4
GBM	COL8A1 →	+1.310	+0.136	<.001	<.001	3	4
COAD	LINC01614 →	+1.877	+0.732	.006	.003	3	4
GBM	LINC01960 →	+0.172	+0.137	<.001	<.001	3	4
BRCA	ANKRD54 →	-0.297	-0.397	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000118 vs COL5A2 — GBM

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