"Regulation of Wnt signaling pathway, planar cell polarity pathway"

Across TCGA patient cohorts, RNA activity of the "Regulation of Wnt signaling pathway, planar cell polarity pathway" pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFRP1, GPC3, and FBN1, each associated with the pathway in up to 27 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of Wnt signaling pathway, planar cell polarity pathway" activity versus SFRP1 in TGCT (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	SFRP1 →	+2.970	+0.115	<.001	<.001	3	27
TGCT	GPC3 →	+5.419	+0.142	<.001	<.001	3	27
PAAD	FBN1 →	+1.625	+0.052	<.001	<.001	3	27
PAAD	FSTL1 →	+1.341	+0.051	<.001	<.001	3	26
TGCT	FLRT2 →	+2.041	+0.145	<.001	<.001	3	26
TGCT	STARD4-AS1 →	+1.010	+0.112	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000095 vs SFRP1 — TGCT

Explore this scatter interactively →