"Regulation of Wnt signaling pathway, planar cell polarity pathway"

Across TCGA patient cohorts, RNA activity of the "Regulation of Wnt signaling pathway, planar cell polarity pathway" pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL5A1, GREM2, and DCLK1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Regulation of Wnt signaling pathway, planar cell polarity pathway" activity versus COL5A1 in OV (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	COL5A1 →	+0.992	+0.451	.008	.002	3	6
OV	GREM2 →	+0.790	+0.827	<.001	<.001	3	5
LSCC	DCLK1 →	+0.642	+0.269	.004	.001	3	5
GBM	LAMA2 →	+0.878	+0.305	.001	.006	3	5
OV	ISLR →	+1.358	+0.674	.001	.002	3	5
OV	CYBRD1 →	+1.021	+0.724	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000095 vs COL5A1 — OV

Explore this scatter interactively →