"Regulation of Wnt signaling pathway, planar cell polarity pathway"

Across TCGA cell cohorts, RNA activity of the "Regulation of Wnt signaling pathway, planar cell polarity pathway" pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF250, RAD54B, and ZNF7, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF250 grouped by "Regulation of Wnt signaling pathway, planar cell polarity pathway"-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZNF250 →	+0.609	+0.971	.007	.007	3	3
BLOOD_Leukemia	RAD54B →	+0.647	+1.089	.001	<.001	3	3
BLOOD_Leukemia	ZNF7 →	+0.551	+1.109	.002	.001	3	3
BLOOD_Leukemia	ZNF623 →	+0.907	+1.454	.001	<.001	3	3
BLOOD_Lymphoma	SFR1 →	-0.806	-1.627	.008	.002	3	3
LUNG_NSCLC_LUAD	ERI2 →	+0.446	+0.627	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF250 by "Regulation of Wnt signaling pathway, planar cell polarity pathway" activity — BLOOD_Leukemia

Explore this box plot interactively →