Negative regulation of ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KATNB1, WDR74, and SSRP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ubiquitin-dependent protein catabolic process activity versus KATNB1 in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	KATNB1 →	+0.516	+0.158	.002	.004	3	6
BONE	WDR74 →	+0.847	+0.448	.004	.002	3	6
OVARY	SSRP1 →	+0.958	+0.308	<.001	<.001	3	6
PANCREAS	ABHD10 →	+0.742	+0.251	<.001	<.001	3	5
BREAST	USP14 →	+0.906	+0.205	<.001	<.001	3	5
BREAST	GRPEL1 →	+0.769	+0.212	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000059 vs KATNB1 — LUNG_NSCLC_LUAD

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