Regulation of non-canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of non-canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TANGO6, ELP1, and CINP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of non-canonical Wnt signaling pathway activity versus TANGO6 in BREAST (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TANGO6 →	+0.803	+0.793	.002	.009	3	5
LUNG_SCLC	ELP1 →	+0.656	+1.313	.008	<.001	3	5
LIVER	CINP →	+0.835	+1.617	.004	<.001	3	5
BREAST	HOXD12 →	+0.083	+0.924	.002	.001	3	4
UPPER_AERODIGESTIVE_TRACT	BAG4 →	+1.078	+1.426	.005	.005	3	4
LARGE_INTESTINE	DNAJC11 →	+0.614	+1.356	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:2000050 vs TANGO6 — BREAST

Explore this scatter interactively →