Xenobiotic transport across blood-brain barrier

Across TCGA patient cohorts, RNA activity of the Xenobiotic transport across blood-brain barrier pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABCB1, ALDH1A1, and ADD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Xenobiotic transport across blood-brain barrier activity versus ABCB1 in COAD (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ABCB1 →	+0.760	+0.096	<.001	<.001	3	6
GBM	ALDH1A1 →	+0.607	+0.090	<.001	.001	3	6
BRCA	ADD1 →	+0.286	+0.046	.002	.001	3	5
BRCA	ADD3 →	+0.405	+0.043	<.001	.002	3	5
UCEC	HSPA12B →	+0.437	+0.093	.003	.003	3	5
GBM	RNLS →	+0.425	+0.070	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990962 vs ABCB1 — COAD

Explore this scatter interactively →