Response to angiotensin

Across TCGA patient cohorts, RNA activity of the Response to angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS3, PTH1R, and DDR2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to angiotensin activity versus RBMS3 in BRCA (Pearson r = 0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RBMS3 →	+0.608	+0.169	<.001	<.001	3	7
BRCA	PTH1R →	+0.688	+0.234	<.001	<.001	3	7
BRCA	DDR2 →	+0.646	+0.182	<.001	<.001	3	7
BRCA	TIMP3 →	+1.101	+0.151	<.001	<.001	3	6
OV	IGDCC4 →	+0.559	+0.270	.001	<.001	3	6
GBM	RUNX2 →	+0.777	+0.174	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990776 vs RBMS3 — BRCA

Explore this scatter interactively →