Response to angiotensin

Across TCGA cell cohorts, RNA activity of the Response to angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAG2, NUP153, and SSRP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BAG2 grouped by Response to angiotensin-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BAG2 →	+1.318	+1.069	<.001	<.001	3	5
BLOOD_Leukemia	NUP153 →	+0.858	+1.230	<.001	<.001	3	5
BREAST	SSRP1 →	+1.079	+1.176	.001	<.001	3	5
BLOOD_Leukemia	CBLL1 →	+0.944	+1.554	<.001	<.001	3	5
OVARY	CUL1 →	+0.525	+1.024	.007	.006	3	5
LARGE_INTESTINE	CCDC77 →	+0.726	+1.119	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAG2 by Response to angiotensin activity — LARGE_INTESTINE

Explore this box plot interactively →