Response to angiotensin

Across TCGA cell cohorts, RNA activity of the Response to angiotensin pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC15A3, MEAK7, and VWA8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to angiotensin activity versus SLC15A3 in PANCREAS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SLC15A3 →	+1.845	+0.279	.002	.002	3	6
PANCREAS	MEAK7 →	+1.281	+0.324	<.001	.008	3	6
LARGE_INTESTINE	VWA8 →	-0.650	-0.290	<.001	.008	3	5
SKIN	PAM16 →	-0.558	-0.237	.003	.008	3	5
LUNG_NSCLC_LUAD	DSE →	+1.295	+0.145	.003	.008	3	5
LUNG_SCLC	PPAT →	-0.780	-0.627	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990776 vs SLC15A3 — PANCREAS

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