Cellular response to brain-derived neurotrophic factor stimulus

Across TCGA cell cohorts, RNA activity of the Cellular response to brain-derived neurotrophic factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCS, NRDC, and LYRM9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to brain-derived neurotrophic factor stimulus activity versus CCS in BLOOD_Leukemia (Pearson r = -0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CCS →	-0.537	-0.114	<.001	<.001	3	4
CNS	NRDC →	+0.710	+0.133	.004	.007	3	4
BLOOD_Leukemia	LYRM9 →	-1.477	-0.149	<.001	<.001	3	4
BLOOD_Leukemia	DNTTIP2 →	+0.499	+0.128	.004	<.001	3	4
BLOOD_Leukemia	YPEL3 →	-2.385	-0.162	<.001	<.001	3	4
BREAST	BCAM →	-2.999	-0.161	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990416 vs CCS — BLOOD_Leukemia

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