Replication-born double-strand break repair via sister chromatid exchange

Across TCGA patient cohorts, RNA activity of the Replication-born double-strand break repair via sister chromatid exchange pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are XRCC1_S241, MCM4_T110, and RFC4, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Replication-born double-strand break repair via sister chromatid exchange activity versus XRCC1_S241 in LSCC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	XRCC1_S241 →	+0.959	+0.096	<.001	<.001	3	10
GBM	MCM4_T110 →	+1.118	+0.076	<.001	<.001	3	10
LSCC	RFC4 →	+0.524	+0.094	<.001	<.001	3	9
LSCC	RPL12_S38 →	+1.034	+0.092	<.001	<.001	3	9
BRCA	ATAD2 →	+0.773	+0.062	<.001	<.001	3	9
GBM	SETDB1_S1066 →	+1.042	+0.102	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990414 vs XRCC1_S241 — LSCC

Explore this scatter interactively →