Gap junction-mediated intercellular transport

Across TCGA patient cohorts, RNA activity of the Gap junction-mediated intercellular transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU6-517P, MCRIP1, and RPS26P18, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Gap junction-mediated intercellular transport activity versus RNU6-517P in LSCC (Pearson r = -0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNU6-517P →	-1.430	-0.308	.003	.006	3	2
LSCC	MCRIP1 →	-0.846	-0.327	.001	<.001	3	2
HNSC	RPS26P18 →	-1.129	-0.850	<.001	.003	3	2
LSCC	POLHP1 →	-0.763	-0.344	.001	.004	3	2
LSCC	TRBVA →	-0.601	-0.358	.004	.002	3	2
LSCC	RASSF8-AS1 →	-0.905	-0.385	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990349 vs RNU6-517P — LSCC

Explore this scatter interactively →