Negative regulation of lipid localization

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipid localization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRYL1, SNX9, and VCL_S579, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid localization activity versus CRYL1 in BRCA (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CRYL1 →	+0.400	+0.034	<.001	<.001	3	7
OV	SNX9 →	+0.291	+0.034	.001	.001	3	6
BRCA	VCL_S579 →	+0.552	+0.032	.001	.004	3	6
BRCA	CYGB →	+0.488	+0.044	.002	<.001	3	6
BRCA	ILK →	+0.468	+0.044	<.001	<.001	3	6
LSCC	CES1 →	+0.854	+0.037	.005	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905953 vs CRYL1 — BRCA

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