Negative regulation of lipid localization

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipid localization pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IRS2, VSIG4, and ABCA1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid localization activity versus IRS2 in OV (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	IRS2 →	+1.318	+0.189	<.001	<.001	3	7
GBM	VSIG4 →	+0.800	+0.145	.001	.001	3	5
GBM	ABCA1 →	+0.547	+0.162	<.001	.004	3	5
LSCC	RENBP →	+0.578	+0.266	<.001	<.001	3	4
COAD	MS4A4A →	+0.716	+0.627	.008	.001	3	4
GBM	CD163 →	+1.134	+0.161	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905953 vs IRS2 — OV

Explore this scatter interactively →