Positive regulation of spindle assembly

Across TCGA patient cohorts, RNA activity of the Positive regulation of spindle assembly pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1106, LIG1, and UNG_T60, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of spindle assembly activity versus TOP2A_S1106 in UCEC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TOP2A_S1106 →	+1.053	+0.106	<.001	<.001	3	10
HNSC	LIG1 →	+0.448	+0.062	<.001	.001	3	10
LUAD	UNG_T60 →	+0.744	+0.082	<.001	<.001	3	10
LSCC	RFC2 →	+0.447	+0.099	<.001	<.001	3	9
GBM	RRM2 →	+0.808	+0.093	<.001	.001	3	9
GBM	SETDB1_S1066 →	+1.342	+0.155	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905832 vs TOP2A_S1106 — UCEC

Explore this scatter interactively →