Regulation of artery morphogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of artery morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKT3_S34, SHTN1, and SON, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of artery morphogenesis activity versus AKT3_S34 in LSCC (Pearson r = 0.61).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKT3_S34 →	+1.016	+0.193	<.001	<.001	3	5
COAD	SHTN1 →	-0.287	-0.067	<.001	<.001	3	4
COAD	SON →	-0.117	-0.050	<.001	<.001	3	4
BRCA	C1S →	+0.520	+0.083	<.001	<.001	3	4
COAD	DYSF →	+0.252	+0.049	.003	.003	3	4
COAD	LRP1 →	+0.215	+0.057	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905651 vs AKT3_S34 — LSCC

Explore this scatter interactively →