Regulation of mitochondrial ATP synthesis coupled electron transport

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial ATP synthesis coupled electron transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOP2A_S1377, DDX21_S89, and EIF3H_S183, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial ATP synthesis coupled electron transport activity versus TOP2A_S1377 in OV (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TOP2A_S1377 →	+1.091	+0.076	<.001	.002	3	10
LUAD	DDX21_S89 →	+0.958	+0.103	<.001	<.001	3	10
BRCA	EIF3H_S183 →	+0.684	+0.070	<.001	<.001	3	10
OV	RPL12_S38 →	+1.175	+0.081	<.001	<.001	3	9
LUAD	RRM2 →	+0.680	+0.114	<.001	<.001	3	9
LUAD	ATAD2_S342 →	+1.309	+0.115	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905446 vs TOP2A_S1377 — OV

Explore this scatter interactively →