Regulation of lysosomal protein catabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of lysosomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBL1, MATN1-AS1, and STARD10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosomal protein catabolic process activity versus RBL1 in LSCC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBL1 →	-0.522	-0.279	.003	.004	2	5
LUAD	MATN1-AS1 →	-0.290	-0.226	.007	.001	3	4
HNSC	STARD10 →	+0.628	+0.129	.001	<.001	3	4
CCRCC	SLC4A4 →	+1.170	+0.274	<.001	<.001	3	4
BRCA	FBP1 →	+1.033	+0.519	.003	.002	3	4
CCRCC	ZNF101 →	-0.191	-0.188	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905165 vs RBL1 — LSCC

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