Regulation of lysosomal protein catabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of lysosomal protein catabolic process pathway is associated with patient survival in 17 of 34 cancer lineages. Pathway activity is summarized from the expression of its 10 member genes.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher Regulation of lysosomal protein catabolic process pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRP and UCEC, show the opposite pattern, with higher activity associated with better survival.

KIRP, UCEC, and UCS are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.721	0.335	<.001	151	view →
UCEC	OS	Tertile	II,III,IV	0.789	0.415	.002	106	view →
UCS	OS	Tertile	IV	0.844	0.228	.024	30	view →
LUSC	OS	Quartile	All	0.507	0.329	.003	25	view →
MESO	OS	Median	II,III,IV	0.344	0.701	.006	21	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	17	view →
KICH	DFS	Tertile	II,III,IV	0.351	0.916	.005	15	view →
ESCA	OS	Quartile	III,IV	0.669	0.277	.009	14	view →
THCA	DFS	Quartile	All	1.000	0.745	.011	12	view →
SKCM	OS	Tertile	All	0.370	0.249	.017	10	view →
GBM	OS	Median	All	0.463	0.243	.026	9	view →
READ	DFS	Tertile	IV	0.228	0.773	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

GO:1905165–KIRP (OS)

Open the KIRP breakdown →