Regulation of lysosomal protein catabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of lysosomal protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPN1, CCDC106, and B3GNT9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lysosomal protein catabolic process activity versus PABPN1 in OESOPHAGUS (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PABPN1 →	-0.634	-0.687	.001	.005	3	4
KIDNEY	CCDC106 →	-1.814	-0.291	.002	<.001	3	4
LARGE_INTESTINE	B3GNT9 →	+1.090	+0.685	.001	.004	3	4
LIVER	PYGO2 →	-0.661	-0.252	<.001	.006	3	4
OESOPHAGUS	CCDC137 →	-0.675	-0.903	.008	.004	3	4
OVARY	SSR4 →	+1.077	+1.234	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905165 vs PABPN1 — OESOPHAGUS

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