Negative regulation of receptor signaling pathway via STAT

Across TCGA patient cohorts, RNA activity of the Negative regulation of receptor signaling pathway via STAT pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, PALM2AKAP2_S393, and CCDC88A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of receptor signaling pathway via STAT activity versus NID2 in UCEC (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NID2 →	+0.848	+0.094	<.001	<.001	3	6
LSCC	PALM2AKAP2_S393 →	+0.489	+0.061	<.001	<.001	3	6
LUAD	CCDC88A →	+0.212	+0.042	<.001	<.001	3	6
CCRCC	TTC39A →	-0.487	-0.048	.005	.006	3	5
UCEC	COG7 →	-0.225	-0.074	<.001	<.001	3	5
COAD	RAB31 →	+0.299	+0.020	.002	.009	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904893 vs NID2 — UCEC

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