Regulation of excitatory synapse assembly

Across TCGA patient cohorts, RNA activity of the Regulation of excitatory synapse assembly pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MALL, PTPN13, and LGALS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of excitatory synapse assembly activity versus MALL in LSCC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MALL →	+0.935	+0.567	<.001	<.001	3	5
LUAD	PTPN13 →	+1.287	+0.809	<.001	<.001	3	5
CCRCC	LGALS2 →	+1.080	+0.328	.003	.001	3	4
GBM	TDO2 →	-1.005	-0.633	<.001	<.001	3	4
GBM	EGFLAM-AS2 →	-0.171	-0.580	.001	.009	3	4
BRCA	TFEB →	+0.497	+0.594	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904889 vs MALL — LSCC

Explore this scatter interactively →