Cranial skeletal system development

Across TCGA cell cohorts, RNA activity of the Cranial skeletal system development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ASCC1, AMPH, and CCT4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cranial skeletal system development activity versus ASCC1 in BLOOD_Leukemia (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASCC1 →	-0.701	-0.171	<.001	<.001	3	5
CNS	AMPH →	+2.671	+0.258	<.001	<.001	3	5
LUNG_SCLC	CCT4 →	-0.530	-0.245	.006	.006	3	5
SKIN	MRPL45 →	-0.355	-0.167	.003	.005	2	5
OESOPHAGUS	NCF1 →	+0.391	+0.191	.003	.002	3	4
OESOPHAGUS	ADAM20 →	+0.192	+0.256	.005	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904888 vs ASCC1 — BLOOD_Leukemia

Explore this scatter interactively →