Regulation of protein localization to cell cortex

Across TCGA patient cohorts, RNA activity of the Regulation of protein localization to cell cortex pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC1_T506, ATAD2, and TOP2A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell cortex activity versus RFC1_T506 in PDAC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RFC1_T506 →	+0.942	+0.053	<.001	<.001	3	9
BRCA	ATAD2 →	+0.605	+0.048	<.001	<.001	3	9
BRCA	TOP2A →	+0.828	+0.045	<.001	<.001	3	9
PDAC	TOP2A_S1377 →	+1.084	+0.058	<.001	<.001	3	9
UCEC	TPX2 →	+0.954	+0.090	<.001	<.001	3	9
BRCA	TPX2_S738 →	+1.145	+0.051	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904776 vs RFC1_T506 — PDAC

Explore this scatter interactively →