Regulation of protein localization to cell cortex

Across TCGA cell cohorts, RNA activity of the Regulation of protein localization to cell cortex pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNAI1, RABGEF1, and CNBP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of protein localization to cell cortex activity versus GNAI1 in LUNG_SCLC (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GNAI1 →	+1.349	+0.276	.001	.001	3	4
LUNG_SCLC	RABGEF1 →	+0.344	+0.211	.006	.002	3	4
LUNG_SCLC	CNBP →	-0.410	-0.210	.003	.002	3	4
BREAST	GGA2 →	-0.745	-0.177	<.001	.001	3	4
SKIN	QKI →	+1.198	+0.394	<.001	.006	3	3
URINARY_TRACT	FCHSD2 →	+1.363	+0.314	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904776 vs GNAI1 — LUNG_SCLC

Explore this scatter interactively →