Regulation of ubiquitin protein ligase activity

Across TCGA patient cohorts, RNA activity of the Regulation of ubiquitin protein ligase activity pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BAG2, HJURP, and KIF23, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ubiquitin protein ligase activity activity versus BAG2 in OV (Pearson r = 0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BAG2 →	+0.853	+0.180	.004	.005	3	7
OV	HJURP →	+0.873	+0.210	<.001	<.001	3	6
LSCC	KIF23 →	+0.722	+0.208	<.001	<.001	3	6
LSCC	TTK →	+0.988	+0.222	<.001	<.001	3	5
BRCA	KIF14 →	+0.723	+0.142	.003	.001	3	5
LSCC	TOP2A →	+0.791	+0.180	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904666 vs BAG2 — OV

Explore this scatter interactively →