Response to glycoprotein

Across TCGA patient cohorts, RNA activity of the Response to glycoprotein pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD19, IGHV3-7, and CD33, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to glycoprotein activity versus CD19 in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CD19 →	+1.005	+0.140	<.001	.001	3	5
GBM	IGHV3-7 →	+1.247	+0.231	.003	.001	3	5
GBM	CD33 →	+0.838	+0.337	<.001	<.001	3	4
BRCA	P2RX1 →	+0.704	+0.364	.002	.009	2	5
GBM	MS4A6A →	+1.086	+0.271	<.001	<.001	3	4
BRCA	IL10RA →	+0.785	+0.369	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904587 vs CD19 — LSCC

Explore this scatter interactively →