Response to glycoprotein

Across TCGA cell cohorts, RNA activity of the Response to glycoprotein pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERAC1, IPO13, and CLDND2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SERAC1 grouped by Response to glycoprotein-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SERAC1 →	-0.521	-0.949	.009	<.001	3	5
BREAST	IPO13 →	-0.482	-0.793	.003	<.001	3	4
BLOOD_Myeloma	CLDND2 →	+0.980	+1.804	.002	<.001	3	4
SOFT_TISSUE	RPS13 →	+0.719	+2.003	<.001	<.001	3	4
PANCREAS	ANKFY1 →	-0.649	-1.527	.002	<.001	3	4
SOFT_TISSUE	ATP13A1 →	-0.663	-1.767	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SERAC1 by Response to glycoprotein activity — BREAST

Explore this box plot interactively →