Regulation of telomere maintenance in response to DNA damage

Across TCGA patient cohorts, RNA activity of the Regulation of telomere maintenance in response to DNA damage pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INO80B, INO80C, and CENPT, each associated with the pathway in up to 31 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of telomere maintenance in response to DNA damage activity versus INO80B in ACC (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	INO80B →	+0.874	+0.038	<.001	<.001	3	30
SCLC	INO80C →	+1.455	+0.079	<.001	.001	2	31
KICH	CENPT →	+1.002	+0.030	.001	<.001	2	29
DLBC	ARL6IP4 →	+0.747	+0.046	<.001	.001	2	29
KICH	NPIPP1 →	+1.296	+0.025	.003	.007	1	30
KIRC	CHKB →	+1.091	+0.044	<.001	<.001	3	27

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904505 vs INO80B — ACC

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