Q-omics provides the consensus-scored NPIPP1 profile across patient tissues and cancer cell-line models. NPIPP1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, NPIPP1 is differentially expressed in 13, with the highest sampling consensus in KIRC. Additionally, NPIPP1 RNA expression shows 16,570 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KIRC, and THYM as cancer lineages where NPIPP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NPIPP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NPIPP1 survival associations across molecular data types. NPIPP1 RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NPIPP1 RNA expression–survival associations across cancer types. High NPIPP1 expression shows unfavorable associations in KIRC, ACC, LIHC and KICH, but favorable associations in PAAD and SKCM. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for NPIPP1 RNA expression.
This table summarizes NPIPP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for NPIPP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NPIPP1 shows lower tumor expression in BRCA and THCA and higher tumor expression in KIRC, LIHC, COAD and KIRP. The KIRC box plot shows higher NPIPP1 RNA expression in tumor versus normal tissue (log2 FC = +1.087, t-test p < 0.001).
This table shows molecular features associated with NPIPP1 in patient tissues and cancer cell lines. In patient samples, NPIPP1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
