Regulation of lipophagy

Across TCGA cell cohorts, RNA activity of the Regulation of lipophagy pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ANKRD6, SMC4, and TNIP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipophagy activity versus ANKRD6 in CNS (Pearson r = 0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ANKRD6 →	+4.050	+0.227	.004	.003	3	2
BLOOD_Lymphoma	SMC4 →	-1.110	-1.201	<.001	<.001	3	2
BLOOD_Lymphoma	TNIP2 →	+1.225	+1.012	<.001	<.001	3	2
BLOOD_Lymphoma	EID2 →	-0.773	-1.432	.001	<.001	3	2
BLOOD_Lymphoma	SLC12A8 →	+2.222	+0.966	.009	.001	2	3
LUNG_NSCLC_LUAD	DELE1 →	-1.517	-0.329	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904502 vs ANKRD6 — CNS

Explore this scatter interactively →