Regulation of lipophagy

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of lipophagy pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Regulation of lipophagy pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SCLC and UVM, show the opposite pattern, with higher activity associated with better survival.

MESO, PCPG, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	III,IV	0.234	0.464	<.001	67	view →
PCPG	DFS	Quartile	All	0.551	0.969	<.001	33	view →
SKCM	OS	Quartile	III,IV	0.662	0.906	.006	30	view →
SCLC	OS	Median	II,III,IV	0.602	0.276	.001	27	view →
KIRC	DFS	Quartile	II,III,IV	0.282	0.617	.004	26	view →
UVM	OS	Tertile	All	1.000	0.802	.009	22	view →
DLBC	DFS	Median	II,III,IV	0.567	0.971	.016	14	view →
KICH	DFS	Tertile	All	0.801	1.000	.017	13	view →
LUAD	DFS	Quartile	All	0.592	0.283	.019	12	view →
CHOL	OS	Median	II,III,IV	0.253	0.796	.018	12	view →
LGG	DFS	Tertile	All	0.340	0.537	.002	12	view →
PAAD	DFS	Tertile	All	0.414	0.151	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:1904502–MESO (DFS)

Open the MESO breakdown →