Regulation of neuromuscular junction development

Across TCGA patient cohorts, RNA activity of the Regulation of neuromuscular junction development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MYCBP2-AS1, RNU6-516P, and PRSS3P4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuromuscular junction development activity versus MYCBP2-AS1 in UCEC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYCBP2-AS1 →	+0.374	+0.802	<.001	<.001	3	4
LSCC	RNU6-516P →	+0.513	+0.424	.006	.009	3	3
LSCC	PRSS3P4 →	+0.529	+0.460	.007	.005	3	3
GBM	MYCBP2 →	+0.350	+0.872	.004	<.001	3	3
BRCA	PHYH →	-0.738	-0.947	<.001	<.001	3	3
BRCA	NEDD9 →	-0.579	-0.686	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904396 vs MYCBP2-AS1 — UCEC

Explore this scatter interactively →