Response to L-phenylalanine derivative

Across TCGA cell cohorts, RNA activity of the Response to L-phenylalanine derivative pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM38A, TCF19, and CDRT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to L-phenylalanine derivative activity versus TMEM38A in BLOOD_Lymphoma (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TMEM38A →	-1.941	-0.151	<.001	.001	3	6
LUNG_NSCLC_LUAD	TCF19 →	-0.874	-0.123	.004	.008	3	5
LUNG_NSCLC_LUAD	CDRT1 →	+1.233	+0.176	.002	<.001	3	5
URINARY_TRACT	HDAC1 →	-0.547	-0.219	.007	.008	3	5
PANCREAS	HNRNPR →	-0.616	-0.145	.009	.002	3	5
LIVER	SQSTM1 →	+1.956	+0.298	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904386 vs TMEM38A — BLOOD_Lymphoma

Explore this scatter interactively →