Response to sodium phosphate

Across TCGA cell cohorts, RNA activity of the Response to sodium phosphate pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLAIN1, THRAP3, and SRP54, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to sodium phosphate activity versus SLAIN1 in OESOPHAGUS (Pearson r = 0.93).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLAIN1 →	+1.677	+0.203	.004	.002	3	2
LARGE_INTESTINE	THRAP3 →	+1.444	+0.373	.009	.007	3	2
LUNG_NSCLC_LUAD	SRP54 →	+0.665	+0.345	.002	.002	3	2
LUNG_NSCLC_LUAD	SMCHD1 →	+0.972	+0.342	.009	.001	3	2
LUNG_NSCLC_LUAD	URI1 →	+0.792	+0.375	.003	.001	3	2
LUNG_NSCLC_LUAD	MRC2 →	+4.017	+0.314	.008	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904383 vs SLAIN1 — OESOPHAGUS

Explore this scatter interactively →