Positive regulation of protein localization to cell periphery

Across TCGA cell cohorts, RNA activity of the Positive regulation of protein localization to cell periphery pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LGR6, STAR, and MAP2K3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LGR6 grouped by Positive regulation of protein localization to cell periphery-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LGR6 →	-0.241	-0.094	.002	.001	3	6
STOMACH	STAR →	-0.128	-0.103	.006	.001	3	6
CNS	MAP2K3 →	-0.194	-0.066	.002	<.001	3	5
STOMACH	KLF5 →	+0.361	+0.107	.001	<.001	3	5
CNS	MAX →	-0.513	-0.076	<.001	.001	3	4
URINARY_TRACT	RPA1 →	+0.725	+0.116	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LGR6 by Positive regulation of protein localization to cell periphery activity — OESOPHAGUS

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