Negative regulation of ERAD pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of ERAD pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PACC1, HNRNPM_S701, and ZYX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERAD pathway activity versus PACC1 in UCEC (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PACC1 →	+0.651	+0.070	<.001	<.001	3	4
LSCC	HNRNPM_S701 →	+0.692	+0.074	<.001	<.001	3	4
LSCC	ZYX →	-0.247	-0.054	.007	.006	3	4
PDAC	CAMSAP3_S769 →	+0.431	+0.039	<.001	.004	3	4
LSCC	SAFB →	+0.181	+0.050	.001	.001	3	4
LSCC	SGTA →	+0.310	+0.069	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904293 vs PACC1 — UCEC

Explore this scatter interactively →