Negative regulation of ERAD pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MPV17L2, BOLA3P4, and C4orf19, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERAD pathway activity versus MPV17L2 in UCEC (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MPV17L2 →	+0.535	+0.100	.003	.005	3	4
GBM	BOLA3P4 →	+0.428	+0.190	.001	.002	3	3
OV	C4orf19 →	+0.815	+0.205	.001	.004	3	3
UCEC	ANO9 →	+0.481	+0.102	.006	.003	3	3
LUAD	COPE →	+0.257	+0.167	.003	.001	3	3
LUAD	ART4 →	-0.507	-0.214	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904293 vs MPV17L2 — UCEC

Explore this scatter interactively →