Negative regulation of ERAD pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of ERAD pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HACE1_S385, SLK_S565, and SRRM1_T614, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERAD pathway activity versus HACE1_S385 in PDAC (Pearson r = -0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	HACE1_S385 →	-1.262	-0.174	<.001	.001	3	4
OV	SLK_S565 →	+1.474	+0.408	<.001	.002	3	3
LSCC	SRRM1_T614 →	+0.227	+0.163	<.001	.001	3	3
PDAC	TACC1_S153 →	-1.246	-0.219	.002	.001	3	3
PDAC	USP42 →	+0.729	+0.296	.001	<.001	3	3
PDAC	ZFYVE16_S946 →	-0.640	-0.163	.001	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904293 vs HACE1_S385 — PDAC

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