Negative regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERAD pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SGTA, UBXN1, and USP25, each associated with the pathway in up to 15 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SGTA grouped by Negative regulation of ERAD pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SGTA →	-0.496	-2.140	.006	.001	3	15
PANCREAS	UBXN1 →	-0.327	-1.761	.002	.001	3	11
PANCREAS	USP25 →	-0.348	-2.068	.002	<.001	3	9
SKIN	USP14 →	-0.209	-1.007	<.001	<.001	3	8
CNS	KCNK9 →	-0.195	-1.043	.008	.007	3	6
KIDNEY	MLC1 →	-0.443	-1.315	.006	.009	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SGTA by Negative regulation of ERAD pathway activity — BONE

Explore this box plot interactively →