Negative regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTA2, ZBTB47, and CACNB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACTA2 grouped by Negative regulation of ERAD pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ACTA2 →	-2.662	-0.920	.001	.005	3	4
BLOOD_Myeloma	ZBTB47 →	-1.486	-1.395	.002	.002	2	5
BLOOD_Lymphoma	CACNB1 →	-1.102	-1.733	<.001	<.001	3	4
LARGE_INTESTINE	MYO1A →	+2.983	+1.118	.001	.001	3	4
LARGE_INTESTINE	PRR15 →	+2.229	+1.093	.009	.002	3	4
BONE	LSM14B →	+0.743	+1.598	.004	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACTA2 by Negative regulation of ERAD pathway activity — CNS

Explore this box plot interactively →