Negative regulation of ERAD pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of ERAD pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBXN2A, USP25, and SVIP, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of ERAD pathway activity versus UBXN2A in KIDNEY (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	UBXN2A →	+0.778	+0.122	<.001	<.001	3	13
OVARY	USP25 →	+1.064	+0.111	<.001	<.001	3	12
LUNG_SCLC	SVIP →	+1.839	+0.153	<.001	<.001	3	10
STOMACH	DPH3 →	+0.829	+0.126	<.001	<.001	3	9
BONE	RAB28 →	+0.563	+0.069	.002	<.001	3	9
LIVER	SUMO1 →	+0.836	+0.116	<.001	.003	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1904293 vs UBXN2A — KIDNEY

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